PAULYLAB

WELCOME TO THE PAULY LABORATORY

We are a research team focusing on the role of the complement system in ocular diseases 

– a true “compliment to the eye".

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The complement system is part of the innate immune response and plays a pivotal role in the development and progression of many ocular diseases. We aim to understand its involvement in the homeostasis of retinal pigment epithelial cells in age-related macular degeneration (AMD) and geographic atrophy, and we search for complement-related biomarkers in patient samples such as aqueous humour.

In many multifactorial diseases, too many factors are studied in isolation, causing us to miss crucial interactions. That's why we strive to understand the complement system in the broader context of retinal function. It's a complex approach, but only by capturing the full interplay of processes can we develop new therapeutic strategies in the long run.

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From October 2026 the lab is part of the Department of Ophthalmology at Leipzig University. Part of our team stays in Marburg, where the lab continues as a guest professorship at the Philipps-University Marburg.

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Click here to find out more about our team and our projects.

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